Effects of San-yu-tang on the Cycloheximide-induced Amnesia in Rats

نویسندگان

  • Ming-Chin Lu
  • Ying-Chih Lin
  • Wen-Huang Peng
  • Chung-Chun Chen
چکیده

The effects of San-Yu-Tang (SYT) on cycloheximide (CXM)-induced amnesia were assessed by passive avoidance in rats. Oral SYT administration (0.5 or 1 g/kg for 1 week) significantly prolonged step-through latency in the amnesic animals. This beneficial effect of SYT on CXM-induced amnesia was enhanced by 8-OH-DPAT (a partial agonist of the 5-HT1A receptor), but reduced by scopolamine (a muscarinic antagonist) and p-chloroamphetamine (a 5-HT releaser) and baclofen (a GAGAB receptor antagonist). These results suggest that SYT enhances memory functions in amnesic rats, at least in part, by increasing the activity of the muscarinic and GABAB receptors, and decreasing the activity of the serotoninergic system.

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تاریخ انتشار 2004